I would actually like to have a bit more information available such as what application you are trying to load. Read through my suggestions and try the ones that seem as though they might be useful for you.
Run chkdsk
In order to rectify any disk errors, you should run the chkdsk utility. It will check for problems related to lost clusters, cross-linked files, directory errors, and bad sectors. To do so, follow this path: Click Start→ click Run→ Type cmd→ press enter. At the prompt, type in chkdsk volume:/r in order to recover readable information, locate bad sectors, and repair errors.
Repair and Restore the Operating System
When it comes to troubleshooting problems in Vista, repairing and restoring the operating system is important. For detailed instructions on how to do so, refer to the article found at this link: Microsoft936212. This strategy will scan and replace system files.
Recovering Files after a Custom Installation of Vista
When Windows Vista is installed on the computer, it creates a backup or folder of the existing files for recovery. This folder is called “Windows.old” folder. To locate this particular folder, you can click Start→ type “drive:\windows.old” in the search box→ click Windows.old in the programs list.
Missing HDD Recovery Folder: Run a Data Recovery Utility
Whenever files or folders go missing, computer users have the option to use a data recovery utility to relocate them. This is one of the quickest methods to retrieve missing files and folders. One program that I can recommend, having tried it myself is Data Recovery Pro from ParetoLogic. This application quickly locates all recoverable data, files, and folders. You can access a free scan and run it to see if it will locate the missing folder. You can learn more about this application at Data Recovery.
Technical Support
If none of the above measures has been helpful, perhaps you can check into the technical support that is available at Filetonic Support.
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